DSIP
Status unknownAlso known as: Emideltide, 62568-57-4, DSIP nonapeptide, Emideltide [INN], DELTA SLEEP-INDUCING PEPTIDE, emideltida, Delta sleep-inducing peptide (rabbit), UNII-YN28Z5YZ73
DSIP (Emideltide, 62568-57-4, DSIP nonapeptide) is classified under nootropic & regulatory peptides.
What the research says
Aggregated from the cited literature below. We summarize sources — we don't author claims.
Delta sleep-inducing peptide (DSIP) (also referred to in sources as emideltide/DSIP nonapeptide) was isolated from rabbit cerebral venous blood (reported as 1977 in a mini-review) and has historically been investigated as a sleep-associated humoral factor; however, the link between DSIP and sleep is described as poorly characterized and still weak due in part to missing information about the DSIP gene, protein, and possible receptor. Research has also evaluated DSIP and DSIP-related materials in relation to sleep physiology, neurotransmitter levels, and DSIP-like immunoreactivity in brain/peripheral tissues and in cerebrospinal fluid in disease contexts. (PMIDs: 16539679, 3550726, 6145137, 2448424)
Mechanism (as reported)
A possible mechanism involving modulation of adrenergic transmission was described as requiring further establishment. (PMID: 3550726)
Key findings (each cites a source)
- Research reported that DSIP was isolated from rabbit cerebral venous blood (Schoenenberger-Monnier group) and that it was initially regarded as a candidate sleep-promoting factor, but the link between DSIP and sleep has never been further characterized and remains weak due to lack of isolation of the DSIP gene/protein and possible related receptor. [PMID 16539679]
- A mini-review reported that DSIP natural occurrence and biological activity remain obscure, and proposed a hypothesis for the existence of DSIP-like peptide(s) contributing to DSIP-like immunoreactivity and DSIP biological activity. [PMID 16539679]
- A review reported that DSIP-like material has been detected using RIA and immunohistochemistry in brain and using RIA in peripheral organs of rat and plasma of several mammals, and described multiple observed effects beyond sleep (including electrophysiological activity, neurotransmitter levels, circadian/locomotor patterns, hormonal levels, psychological performance, and effects on neuropharmacological drugs including withdrawal). [PMID 6145137]
- A review reported that, besides sleep effects, functions of DSIP and a possible mechanism of action involving modulation of adrenergic transmission remain to be established. [PMID 3550726]
- Research investigated a PCPA-induced insomnia mouse model for DSIP fusion peptides (DSIP-CBBBP) and reported changes in neurotransmitter levels (5-HT, glutamate, dopamine, and melatonin) consistent with modulation of neurotransmitter levels and potential sleep-promoting effects in the model. [PMID 39444618]
- A study measured DSIP-like immunoreactivity and phosphorylated DSIP-like immunoreactivity (P-DSIP-LI) in cerebrospinal fluid using radioimmunoassay and reported that mean DSIP-LI and P-DSIP-LI concentrations were significantly higher in an elderly control group than in a middle-aged control group, with positive correlations with age in both control groups. [PMID 2448424]
- In the same CSF study, significant decreases of DSIP-LI (but not described as significant for P-DSIP-LI) were reported in association with multiple conditions (including senile dementia of Alzheimer type subgroups, multi-infarct dementia, Parkinson’s disease, vascular disease, and communicating hydrocephalus) compared with age-matched controls; no significant pathology-related differences were found for P-DSIP-LI. [PMID 2448424]
Independent test grades
No independent third-party test data is available for DSIP yet. Our test grades are aggregated from Finnrick, which independently tests a subset of research peptides — many approved drugs and newer or niche compounds aren't covered.
Research literature (8)
Consolidated from PubMed — each links to the original record.
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Rahman OF, Lee SJ, Seeds WA · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026 · PMID 41490200
- Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models.
Mu X, Qu L, Yin L, Wang L, Liu X, Liu D · Frontiers in pharmacology · 2024 · PMID 39444618
- Delta sleep-inducing peptide (DSIP): a still unresolved riddle.
Kovalzon VM, Strekalova TV · Journal of neurochemistry · 2006 · PMID 16539679
- Delta sleep-inducing peptide.
Pollard BJ, Pomfrett CJ · European journal of anaesthesiology · 2001 · PMID 11437870
- [DSIP: the sleep peptide or an unknown hypothalamic hormone?].
Koval'zon VM · Zhurnal evoliutsionnoi biokhimii i fiziologii · 1994 · PMID 7817664
- Comparison of DSIP- (delta sleep-inducing peptide) and P-DSIP-like (phosphorylated) immunoreactivity in cerebrospinal fluid of patients with senile dementia of Alzheimer type, multi-infarct syndrome, communicating hydrocephalus and Parkinson's disease.
Ernst A, Cramer H, Strubel D, Kuntzmann F, Schoenenberger GA · Journal of neurology · 1987 · PMID 2448424
- Delta-sleep-inducing peptide (DSIP): an update.
Graf MV, Kastin AJ · Peptides · 1986 · PMID 3550726
- Delta-sleep-inducing peptide (DSIP): a review.
Graf MV, Kastin AJ · Neuroscience and biobehavioral reviews · 1984 · PMID 6145137
FAQ
- What is DSIP?
- DSIP (Emideltide, 62568-57-4, DSIP nonapeptide) is classified under nootropic & regulatory peptides. Research goals associated with it include cognitive & mood.
- Is DSIP FDA-approved?
- The regulatory status of DSIP is not established in our sources.
- What does the research on DSIP say?
- peptideone aggregates 8 references from PubMed for DSIP. The summary on this page digests them with citations; we summarize sources and make no efficacy claims.