Gonadorelin
WithdrawnAlso known as: Gonadorelina, GnRH-I, 33515-09-2, Gonadorelinum, Fertagyl, LH-Releasing factor, Luforan, Lutrefact
Gonadorelin (Gonadorelina, GnRH-I, 33515-09-2) is classified under reproductive & hypothalamic peptides, which has been withdrawn from approved use.
Read the full guide: what the research shows on Gonadorelin →What the research says
Aggregated from the cited literature below. We summarize sources — we don't author claims.
Gonadorelin (also referred to as GnRH-I and LH-releasing factor) is discussed in the provided literature as a small peptide hormone/neuropeptide involved in neuroendocrine regulation, with research coverage including analytical methods and broader reproductive-axis biology. It is also mentioned in contexts involving misuse for anti-doping and as a peptide target/analogue class in disease-related reviews.
Mechanism (as reported)
A review of reproductive neuroendocrine regulation describes GnRH as a primary regulator of the hypothalamic–pituitary axis, controlling luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion through pulsatile GnRH release patterns. (PMID: 38778605)
Key findings (each cites a source)
- A review described advances in analytical technology for small peptide hormones and provided a case focused on gonadorelin, discussing analytical approaches including chromatography, immunochemistry, and affinity sensing, and noting trends toward simpler, on-site, faster, and lower-cost analyses. [PMID 36858006]
- The same analytical-technology review described gonadorelin as a neuropeptide that has drawn attention as a therapeutic drug misused for doping practices during sports competitions. [PMID 36858006]
- A review of infertility management described GnRH as a primary reproductive-axis regulator, regulating secretion of LH and FSH, and stated that the pattern of GnRH release is pulsatile and controls endocrine function and gamete maturation. [PMID 38778605]
- A review on infertility-related peptide targets described other peptides (Kisspeptin, Neurokinin-B, Orexin) as influencing positive and negative feedback modulation of GnRH, FSH, and LH secretion, and referenced clinical and preclinical studies in infertility management. [PMID 38778605]
- An oncology review discussed peptide analogs targeting LH-RH in prostate cancer, including depot preparations of LH-RH agonists as a preferred primary treatment approach in advanced androgen-dependent disease and mentions LH-RH antagonists in clinical trials. [PMID 11027415]
Independent HPLC purity tests (10)
Real third-party HPLC results aggregated from Peptigrity, each attributed to the lab that ran it — average purity 99.5% across 10 tests. Not our verdict.
Labs: Ethos Analytics, Vanguard Laboratory, freedomdiagnosticstesting.com, Bioviridian, Janoshik Labs.
| Vendor | HPLC purity | Lab | Date |
|---|---|---|---|
| purehealthpeptides.com | 99.00% | Ethos Analytics | 2026-05-06 |
| corepeptides.com | 99.28% | Vanguard Laboratory | 2026-04-02 |
| kimerachems.co | 99.83% | freedomdiagnosticstesting.com | 2026-03-29 |
| Peptidology | 99.18% | Vanguard Laboratory | 2026-03-23 |
| modernresearchpeptides.net | 99.87% | freedomdiagnosticstesting.com |
Research literature (11)
Consolidated from PubMed — each links to the original record.
- Revolutionizing Infertility Management through Novel Peptide-based Targets.
Kumar V, Doshi G · Current protein & peptide science · 2024 · PMID 38778605
- Advances and perspectives in the analytical technology for small peptide hormones analysis: A glimpse to gonadorelin.
Torrini F, Scarano S, Palladino P, Minunni M · Journal of pharmaceutical and biomedical analysis · 2023 · PMID 36858006
- A biomimetic enzyme-linked immunosorbent assay (BELISA) for the analysis of gonadorelin by using molecularly imprinted polymer-coated microplates.
Torrini F, Caponi L, Bertolini A, Palladino P, Cipolli F, Saba A · Analytical and bioanalytical chemistry · 2022 · PMID 35028691
- Reproductive performance of goats treated with free gonadorelin or nanoconjugated gonadorelin at estrus.
Hashem NM, Sallam SM · Domestic animal endocrinology · 2020 · PMID 31731249
- Neuroendocrinology of ageing.
Rehman HU, Masson EA · Age and ageing · 2001 · PMID 11509304
- Peptide analogs in the therapy of prostate cancer.
Schally AV, Comaru-Schally AM, Plonowski A, Nagy A, Halmos G, Rekasi Z · The Prostate · 2000 · PMID 11027415
- Neuropeptides in the amphibian brain.
Andersen AC, Tonon MC, Pelletier G, Conlon JM, Fasolo A, Vaudry H · International review of cytology · 1992 · PMID 1280630
FAQ
- What is Gonadorelin?
- Gonadorelin (Gonadorelina, GnRH-I, 33515-09-2) is classified under reproductive & hypothalamic peptides, which has been withdrawn from approved use. Research goals associated with it include sexual & reproductive.
- Is Gonadorelin FDA-approved?
- Gonadorelin has been withdrawn from approved use.
- What does the research on Gonadorelin say?
- peptideone aggregates 11 references from PubMed for Gonadorelin. The summary on this page digests them with citations; we summarize sources and make no efficacy claims.