Also known as: 330936-69-1, H975EUX36G, DTXSID70186749, RefChem:146895, DTXCID60109240, HUMANIN TRIFLUOROACETATE, formyl humanin, Protein Humanin (human)
Humanin (330936-69-1, H975EUX36G, DTXSID70186749) is classified under mitochondrial-derived & protective, sold for research use only and not approved for human consumption.
Aggregated from the cited literature below. We summarize sources — we don't author claims.
Humanin is described as a mitochondrial-derived peptide encoded by mitochondrial DNA (mtDNA). Research has investigated humanin as a cytoprotective polypeptide involved in cellular stress responses and apoptosis-related regulation, and it has been discussed in contexts including metabolic regulation, cardiovascular disorders, cancer/degenerative diseases, and reproductive/testicular functions. (PMIDs: 33130077, 32680738, 30582721, 34534645)
Mechanism (as reported)
A review reported that humanin inhibits mitochondrial complex 1 activity and limits oxidative stress in cells. (PMID: 32680738)
Additional review(s) characterized humanin as a cytoprotective peptide regulating signaling mechanisms such as JAK/STAT pathways and interactions involving the BCL-2 family, with reported effects across multiple cell types under stress/apoptosis conditions. (PMIDs: 33130077, 30582721)
Key findings (each cites a source)
Research described humanin as a small mitochondrial-derived cytoprotective polypeptide encoded by mtDNA. (PMIDs: 33130077, 30582721) [PMID 33130077, 30582721]
A study/review described that mitochondrial-derived peptides are regulators of metabolism and discussed humanin’s role in inhibiting mitochondrial complex 1 activity and limiting oxidative stress. (PMID: 32680738) [PMID 32680738]
A review reported that humanin exhibits protective effects against cellular stress and apoptosis across multiple cell types and described involvement of signaling mechanisms such as JAK/STAT and interactions with BCL-2 family proteins. (PMID: 33130077) [PMID 33130077]
A cancer/degenerative diseases-focused review reported that humanin and its analogs have been evaluated as therapeutic targets and discussed potential biomarker value due to detectability in circulation. (PMID: 30582721) [PMID 30582721]
A cardiovascular disorders review reported that humanin was discussed as a possible marker of mitochondrial function in cardiovascular disease and discussed potential connections to endothelial dysfunction. (PMID: 32680738) [PMID 32680738]
Testis-focused research described humanin as being present in testes, predominantly expressed in Leydig cells, and reported moderate expression in germ cells and seminal plasma. (PMID: 34534645) [PMID 34534645]
A testis-focused review reported that humanin was implicated in preventing germ cell apoptosis and participating in IL-12/IL-27 family cytokine-related immune modulation in the testicular environment. (PMID: 34534645) [PMID 34534645]
A buffalo sperm study reported evidence of humanin presence in ejaculated and epididymal spermatozoa and in testicular tissue sections via indirect immunofluorescence. (PMID: 36183493) [PMID 36183493]
The buffalo sperm study reported that humanin supplementation was associated with changes measured in lipid peroxidation, mitochondrial membrane potential, DNA integrity, capacitation/apoptotic status, and zona pellucida binding under cryo-related evaluation. (PMID: 36183493) [PMID 36183493]
Independent HPLC purity tests (1)
Real third-party HPLC results aggregated from Peptigrity, each attributed to the lab that ran it — average purity 99.2% across 1 tests. Not our verdict.
Arakawa T, Hirano A, Shiraki K, Niikura T, Kita Y · Current medicinal chemistry · 2011 · PMID 22172065
FAQ
What is Humanin?
Humanin (330936-69-1, H975EUX36G, DTXSID70186749) is classified under mitochondrial-derived & protective, sold for research use only and not approved for human consumption. Research goals associated with it include longevity & cellular aging.
Is Humanin FDA-approved?
No. Humanin is sold for research use only and is not approved for human consumption.
What does the research on Humanin say?
peptideone aggregates 11 references from PubMed for Humanin. The summary on this page digests them with citations; we summarize sources and make no efficacy claims.