Also known as: 330936-69-1, H975EUX36G, DTXSID70186749, RefChem:146895, DTXCID60109240, HUMANIN TRIFLUOROACETATE, formyl humanin, Protein Humanin (human)
Humanin (330936-69-1, H975EUX36G, DTXSID70186749) is classified under mitochondrial-derived & protective, sold for research use only and not approved for human consumption.
Aggregated from the cited literature below. We summarize sources — we don't author claims.
Humanin is described as a mitochondrial-derived peptide encoded by mitochondrial DNA (mtDNA). Research has investigated humanin as a cytoprotective polypeptide involved in cellular stress responses and apoptosis-related regulation, and it has been discussed in contexts including metabolic regulation, cardiovascular disorders, cancer/degenerative diseases, and reproductive/testicular functions. (PMIDs: 33130077, 32680738, 30582721, 34534645)
Mechanism (as reported)
A review reported that humanin inhibits mitochondrial complex 1 activity and limits oxidative stress in cells. (PMID: 32680738)
Additional review(s) characterized humanin as a cytoprotective peptide regulating signaling mechanisms such as JAK/STAT pathways and interactions involving the BCL-2 family, with reported effects across multiple cell types under stress/apoptosis conditions. (PMIDs: 33130077, 30582721)
Key findings (each cites a source)
Research described humanin as a small mitochondrial-derived cytoprotective polypeptide encoded by mtDNA. (PMIDs: 33130077, 30582721) [PMID 33130077, 30582721]
A study/review described that mitochondrial-derived peptides are regulators of metabolism and discussed humanin’s role in inhibiting mitochondrial complex 1 activity and limiting oxidative stress. (PMID: 32680738) [PMID 32680738]
A review reported that humanin exhibits protective effects against cellular stress and apoptosis across multiple cell types and described involvement of signaling mechanisms such as JAK/STAT and interactions with BCL-2 family proteins. (PMID: 33130077) [PMID 33130077]
A cancer/degenerative diseases-focused review reported that humanin and its analogs have been evaluated as therapeutic targets and discussed potential biomarker value due to detectability in circulation. (PMID: 30582721) [PMID 30582721]
A cardiovascular disorders review reported that humanin was discussed as a possible marker of mitochondrial function in cardiovascular disease and discussed potential connections to endothelial dysfunction. (PMID: 32680738) [PMID 32680738]
Testis-focused research described humanin as being present in testes, predominantly expressed in Leydig cells, and reported moderate expression in germ cells and seminal plasma. (PMID: 34534645) [PMID 34534645]
A testis-focused review reported that humanin was implicated in preventing germ cell apoptosis and participating in IL-12/IL-27 family cytokine-related immune modulation in the testicular environment. (PMID: 34534645) [PMID 34534645]
A buffalo sperm study reported evidence of humanin presence in ejaculated and epididymal spermatozoa and in testicular tissue sections via indirect immunofluorescence. (PMID: 36183493) [PMID 36183493]
The buffalo sperm study reported that humanin supplementation was associated with changes measured in lipid peroxidation, mitochondrial membrane potential, DNA integrity, capacitation/apoptotic status, and zona pellucida binding under cryo-related evaluation. (PMID: 36183493) [PMID 36183493]
Independent test grades
No independent third-party test data is available for Humanin yet. Our test grades are aggregated from Finnrick, which independently tests a subset of research peptides — many approved drugs and newer or niche compounds aren't covered.
Research literature (8)
Consolidated from PubMed — each links to the original record.
Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J · Cell metabolism · 2015 · PMID 25738459
FAQ
What is Humanin?
Humanin (330936-69-1, H975EUX36G, DTXSID70186749) is classified under mitochondrial-derived & protective, sold for research use only and not approved for human consumption. Research goals associated with it include longevity & cellular aging.
Is Humanin FDA-approved?
No. Humanin is sold for research use only and is not approved for human consumption.
What does the research on Humanin say?
peptideone aggregates 8 references from PubMed for Humanin. The summary on this page digests them with citations; we summarize sources and make no efficacy claims.