Matrixyl
Research onlyAlso known as: 214047-00-4, Palmitoyl Pentapeptide-4, L-Serine, N2-(1-oxohexadecyl)-L-lysyl-L-threonyl-L-threonyl-L-lysyl-, Palmitoyl pentapeptide-3, Oristar popp, Lipopentapeptide 3, PAL-Lys-Thr-Thr-Lys-Ser, Palmitoyl pentapeptide-4 [INCI]
Matrixyl (214047-00-4, Palmitoyl Pentapeptide-4, L-Serine, N2-(1-oxohexadecyl)-L-lysyl-L-threonyl-L-threonyl-L-lysyl-) is classified under copper & cosmetic signal peptides, sold for research use only and not approved for human consumption.
Read the full guide: what the research shows on Matrixyl →What the research says
Aggregated from the cited literature below. We summarize sources — we don't author claims.
Matrixyl is described in the provided sources as a collagen-stimulating cosmeceutical peptide ingredient, specifically referring to palmitoyl pentapeptide-4 (also discussed as a palmitoyl derivative of the KTTKS pentapeptide motif). Studies in the sources investigated Matrixyl-related peptides (e.g., C16- or palmitoyl-conjugated KTTKS/PP4 analogues) for effects on fibroblast collagen/ECM-related gene expression, peptide self-assembly, and in some cases antimicrobial/hybrid bioactivity.
Mechanism (as reported)
In vitro research reported that a Matrixyl-associated collagen-stimulating pentapeptide amphiphile (C16-KTTKS; described as a Matrixyl trade-name product) stimulated collagen production by human fibroblasts in a concentration-dependent manner and that this stimulation was inter-related with self-assembly into nanotape structures near the critical aggregation concentration. Another in vitro study reported that combining injectable platelet-rich fibrin (i-PRF) with palmitoyl pentapeptide-4 (Matrixyl) influenced dermal fibroblast viability/proliferation and ECM-related gene expression (COL1A1, FN1, HAS1), with the strongest reported effects occurring with i-PRF + GEKG.
Key findings (each cites a source)
- An in vitro study investigated synergistic effects of injectable platelet-rich fibrin (i-PRF) combined with palmitoyl pentapeptide-4 (Matrixyl) on human dermal fibroblast viability/proliferation and extracellular matrix (ECM)-related gene expression (COL1A1, FN1, HAS1). [PMID 40871567]
- In that in vitro study, combinations of i-PRF with bioactive peptides were reported to upregulate ECM-related genes after 72 h, and the strongest reported synergy was noted for i-PRF + GEKG versus individual treatments. [PMID 40871567]
- A peptide amphiphile study of C16-KTTKS (described as used in antiwrinkle cosmeceutical applications under the Matrixyl trade name) reported that collagen production in human dermal and corneal fibroblasts increased in a concentration-dependent manner near the critical aggregation concentration determined by pyrene fluorescence spectroscopy. [PMID 23320752]
- The C16-KTTKS peptide amphiphile study reported that self-assembly into nanotape structures was inter-related with stimulation of collagen production. [PMID 23320752]
- Research introduced cycloalkane-based lipopeptides conjugated to the collagen-stimulating pentapeptide KTTKS used in Matrixyl formulations and reported compatibility with dermal fibroblasts. [PMID 39422705]
Independent test grades
No independent third-party test data is available for Matrixyl yet. Our test grades are aggregated from Finnrick, which independently tests a subset of research peptides — many approved drugs and newer or niche compounds aren't covered.
Research literature (10)
Consolidated from PubMed — each links to the original record.
- Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides.
de Mello LR, Castelletto V, Seitsonen J, Hamley IW · Journal of peptide science : an official publication of the European Peptide Society · 2026 · PMID 42317129
- Synergistic Effects of Injectable Platelet-Rich Fibrin and Bioactive Peptides on Dermal Fibroblast Viability and Extracellular Matrix Gene Expression: An In Vitro Study.
Paccola AGL, Santos TMCD, Minelo MC, Garbieri TF, Sanches MLR, Dionísio TJ · Molecules (Basel, Switzerland) · 2025 · PMID 40871567
- Self-Assembly and Wound Healing Activity of Biomimetic Cycloalkane-Based Lipopeptides.
Adak A, Castelletto V, Hamley IW, Seitsonen J, Jana A, Ghosh S · ACS applied materials & interfaces · 2024 · PMID 39422705
- Boosting Cosmeceutical Peptides: Coupling Imidazolium-Based Ionic Liquids to Pentapeptide-4 Originates New Leads with Antimicrobial and Collagenesis-Inducing Activities.
Gomes A, Bessa LJ, Fernandes I, Aguiar L, Ferraz R, Monteiro C · Microbiology spectrum · 2022 · PMID 35950860
- Matrixyl Patch vs Matrixyl Cream: A Comparative In Vivo Investigation of Matrixyl (MTI) Effect on Wound Healing.
Kachooeian M, Mousivand Z, Sharifikolouei E, Shirangi M, Firoozpour L, Raoufi M · ACS omega · 2022 · PMID 35874243
- Self-Assembly, Tunable Hydrogel Properties, and Selective Anti-Cancer Activity of a Carnosine-Derived Lipidated Peptide.
Castelletto V, Edwards-Gayle CJC, Greco F, Hamley IW, Seitsonen J, Ruokolainen J · ACS applied materials & interfaces · 2019 · PMID 31407889
FAQ
- What is Matrixyl?
- Matrixyl (214047-00-4, Palmitoyl Pentapeptide-4, L-Serine, N2-(1-oxohexadecyl)-L-lysyl-L-threonyl-L-threonyl-L-lysyl-) is classified under copper & cosmetic signal peptides, sold for research use only and not approved for human consumption. Research goals associated with it include skin, hair & pigmentation.
- Is Matrixyl FDA-approved?
- No. Matrixyl is sold for research use only and is not approved for human consumption.
- What does the research on Matrixyl say?
- peptideone aggregates 10 references from PubMed for Matrixyl. The summary on this page digests them with citations; we summarize sources and make no efficacy claims.