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Matrixyl

Status unknown

Also known as: 214047-00-4, Palmitoyl Pentapeptide-4, L-Serine, N2-(1-oxohexadecyl)-L-lysyl-L-threonyl-L-threonyl-L-lysyl-, Palmitoyl pentapeptide-3, Oristar popp, Lipopentapeptide 3, PAL-Lys-Thr-Thr-Lys-Ser, Palmitoyl pentapeptide-4 [INCI]

Matrixyl (214047-00-4, Palmitoyl Pentapeptide-4, L-Serine, N2-(1-oxohexadecyl)-L-lysyl-L-threonyl-L-threonyl-L-lysyl-) is classified under copper & cosmetic signal peptides.

What the research says

Aggregated from the cited literature below. We summarize sources — we don't author claims.

Matrixyl is described in the provided sources as a collagen-stimulating cosmeceutical peptide ingredient, specifically referring to palmitoyl pentapeptide-4 (also discussed as a palmitoyl derivative of the KTTKS pentapeptide motif). Studies in the sources investigated Matrixyl-related peptides (e.g., C16- or palmitoyl-conjugated KTTKS/PP4 analogues) for effects on fibroblast collagen/ECM-related gene expression, peptide self-assembly, and in some cases antimicrobial/hybrid bioactivity.

Mechanism (as reported)

In vitro research reported that a Matrixyl-associated collagen-stimulating pentapeptide amphiphile (C16-KTTKS; described as a Matrixyl trade-name product) stimulated collagen production by human fibroblasts in a concentration-dependent manner and that this stimulation was inter-related with self-assembly into nanotape structures near the critical aggregation concentration. Another in vitro study reported that combining injectable platelet-rich fibrin (i-PRF) with palmitoyl pentapeptide-4 (Matrixyl) influenced dermal fibroblast viability/proliferation and ECM-related gene expression (COL1A1, FN1, HAS1), with the strongest reported effects occurring with i-PRF + GEKG.

Key findings (each cites a source)

  • An in vitro study investigated synergistic effects of injectable platelet-rich fibrin (i-PRF) combined with palmitoyl pentapeptide-4 (Matrixyl) on human dermal fibroblast viability/proliferation and extracellular matrix (ECM)-related gene expression (COL1A1, FN1, HAS1). [PMID 40871567]
  • In that in vitro study, combinations of i-PRF with bioactive peptides were reported to upregulate ECM-related genes after 72 h, and the strongest reported synergy was noted for i-PRF + GEKG versus individual treatments. [PMID 40871567]
  • A peptide amphiphile study of C16-KTTKS (described as used in antiwrinkle cosmeceutical applications under the Matrixyl trade name) reported that collagen production in human dermal and corneal fibroblasts increased in a concentration-dependent manner near the critical aggregation concentration determined by pyrene fluorescence spectroscopy. [PMID 23320752]
  • The C16-KTTKS peptide amphiphile study reported that self-assembly into nanotape structures was inter-related with stimulation of collagen production. [PMID 23320752]
  • Research introduced cycloalkane-based lipopeptides conjugated to the collagen-stimulating pentapeptide KTTKS used in Matrixyl formulations and reported compatibility with dermal fibroblasts. [PMID 39422705]
  • One study coupled imidazolium-based ionic liquids to a pentapeptide-4 (PP4; described as KTTKS) construct (IL-KTTKS) and reported in vitro antimicrobial activity plus collagenesis-inducing effects comparable to or stronger than Matrixyl. [PMID 35950860]
  • A study reported a hybrid peptide (3.1-PP4) described as retaining the collagenesis-inducing behavior of the Matrixyl-derived reference peptide C16-PP4, alongside antibacterial and anti-biofilm activity against multidrug-resistant Gram-negative bacteria. [PMID 31481944]
  • A related self-assembly/hydrogel study used a C16 hexadecyl lipidated peptide incorporating the KTT sequence from Matrixyl lipopeptides (C16KTTβ2AH) and reported self-assembly into β-sheet nanotape structures above a critical aggregation concentration, with hydrogelation observed and tunable hydrogel modulus. [PMID 31407889]

Independent test grades

No independent third-party test data is available for Matrixyl yet. Our test grades are aggregated from Finnrick, which independently tests a subset of research peptides — many approved drugs and newer or niche compounds aren't covered.

Research literature (8)

Consolidated from PubMed — each links to the original record.

FAQ

What is Matrixyl?
Matrixyl (214047-00-4, Palmitoyl Pentapeptide-4, L-Serine, N2-(1-oxohexadecyl)-L-lysyl-L-threonyl-L-threonyl-L-lysyl-) is classified under copper & cosmetic signal peptides. Research goals associated with it include skin, hair & pigmentation.
Is Matrixyl FDA-approved?
The regulatory status of Matrixyl is not established in our sources.
What does the research on Matrixyl say?
peptideone aggregates 8 references from PubMed for Matrixyl. The summary on this page digests them with citations; we summarize sources and make no efficacy claims.
Aggregated from public sources, with attribution. Not medical advice; compounds discussed are not approved for human consumption. Last updated 2026-06-15.