Palmitoyl Tripeptide-1
Research onlyAlso known as: 147732-56-7, L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-, Palmitoyl oligopeptide, Pal-val-gly-val-ala-pro-gly-oh, DTXSID90163794, RV743D216M, (2S)-6-amino-2-[(2S)-2-(2-hexadecanamidoacetamido)-3-(1H-imidazol-4-yl)propanamido]hexanoic acid, (2S)-6-amino-2-((2S)-2-(2-hexadecanamidoacetamido)-3-(1H-imidazol-4-yl)propanamido)hexanoic acid
Palmitoyl Tripeptide-1 (147732-56-7, L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-, Palmitoyl oligopeptide) is classified under copper & cosmetic signal peptides, sold for research use only and not approved for human consumption.
Read the full guide: what the research shows on Palmitoyl Tripeptide-1 →What the research says
Aggregated from the cited literature below. We summarize sources — we don't author claims.
Palmitoyl Tripeptide-1 (PT-1) is described in the provided literature as a palmitoylated peptide used in a time-coordinated regimen for collagen metabolism and skin outcomes in preclinical and clinical settings. A review source also discusses how palmitoylated GHK derivatives are marketed in anti-wrinkle products and notes limited published clinical information for such derivatives specifically.
Mechanism (as reported)
In a circadian-synchronized human skin fibroblast model, collagen-metabolism gene expression showed day-night phase differences, and a timed intervention was reported to shift collagen metabolism toward synthesis at night with PT-1. (PMID: 41527525)
Key findings (each cites a source)
- A study reported that collagen-metabolism-related gene expression in a circadian-synchronized human skin fibroblast model displayed day-night phase-dependent rhythms, with assembly-related genes peaking during the day and synthesis/secretion and degradation-related genes peaking at night. (PMID: 41527525) [PMID 41527525]
- A study reported that time phase-dependent interventions showed baicalin enhancing daytime collagen assembly while palmitoyl tripeptide-1 (PT-1) boosted nighttime collagen synthesis. (PMID: 41527525) [PMID 41527525]
- A study reported that, in mice, a timed day-night combination regimen including PT-1 increased collagen fiber density. (PMID: 41527525) [PMID 41527525]
- A clinical trial (n=30 female participants) was reported to show significant improvements in skin luminance (+16.29%), nasolabial fold depth (-36.35%), and firmness (R2: +24.35%) using the same time-coordinated day baicalin/night PT-1 scheme. (PMID: 41527525) [PMID 41527525]
- A review reported that GHK and palmitoylated GHK derivatives (e.g., Pal-GHK) are widely used in anti-wrinkle cosmetic products, but that there is a surprising absence of clinical studies using GHK-Cu and Pal-GHK despite interest in skin permeability and cellular studies. (PMID: 39963574) [PMID 39963574]
- A study reported that a LC-MS/MS analytical method enabled reliable assay of palmitoyl peptides in anti-wrinkle creams, and that formulation influenced palmitoyl peptide availability for pal-KTTKS when pal-GHK was used as an internal standard. (PMID: 19393372) [PMID 19393372]