Palmitoyl Tripeptide-1
Status unknownAlso known as: 147732-56-7, L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-, Palmitoyl oligopeptide, Pal-val-gly-val-ala-pro-gly-oh, DTXSID90163794, RV743D216M, (2S)-6-amino-2-[(2S)-2-(2-hexadecanamidoacetamido)-3-(1H-imidazol-4-yl)propanamido]hexanoic acid, (2S)-6-amino-2-((2S)-2-(2-hexadecanamidoacetamido)-3-(1H-imidazol-4-yl)propanamido)hexanoic acid
Palmitoyl Tripeptide-1 (147732-56-7, L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-, Palmitoyl oligopeptide) is classified under copper & cosmetic signal peptides.
What the research says
Aggregated from the cited literature below. We summarize sources — we don't author claims.
Palmitoyl Tripeptide-1 (PT-1) is described in the provided literature as a palmitoylated peptide used in a time-coordinated regimen for collagen metabolism and skin outcomes in preclinical and clinical settings. A review source also discusses how palmitoylated GHK derivatives are marketed in anti-wrinkle products and notes limited published clinical information for such derivatives specifically.
Mechanism (as reported)
In a circadian-synchronized human skin fibroblast model, collagen-metabolism gene expression showed day-night phase differences, and a timed intervention was reported to shift collagen metabolism toward synthesis at night with PT-1. (PMID: 41527525)
Key findings (each cites a source)
- A study reported that collagen-metabolism-related gene expression in a circadian-synchronized human skin fibroblast model displayed day-night phase-dependent rhythms, with assembly-related genes peaking during the day and synthesis/secretion and degradation-related genes peaking at night. (PMID: 41527525) [PMID 41527525]
- A study reported that time phase-dependent interventions showed baicalin enhancing daytime collagen assembly while palmitoyl tripeptide-1 (PT-1) boosted nighttime collagen synthesis. (PMID: 41527525) [PMID 41527525]
- A study reported that, in mice, a timed day-night combination regimen including PT-1 increased collagen fiber density. (PMID: 41527525) [PMID 41527525]
- A clinical trial (n=30 female participants) was reported to show significant improvements in skin luminance (+16.29%), nasolabial fold depth (-36.35%), and firmness (R2: +24.35%) using the same time-coordinated day baicalin/night PT-1 scheme. (PMID: 41527525) [PMID 41527525]
- A review reported that GHK and palmitoylated GHK derivatives (e.g., Pal-GHK) are widely used in anti-wrinkle cosmetic products, but that there is a surprising absence of clinical studies using GHK-Cu and Pal-GHK despite interest in skin permeability and cellular studies. (PMID: 39963574) [PMID 39963574]
- A study reported that a LC-MS/MS analytical method enabled reliable assay of palmitoyl peptides in anti-wrinkle creams, and that formulation influenced palmitoyl peptide availability for pal-KTTKS when pal-GHK was used as an internal standard. (PMID: 19393372) [PMID 19393372]
- A study investigated model Schiff-base formation between an oxoacylglycerol derivative (2-MAG-ALD) and various amino acids/peptides, reporting that Schiff base adducts can be formed and analyzed by HPLC/ESI/MS in designed aqueous or hydrophobic-mimicking conditions. (PMID: 10230725) [PMID 10230725]
- A cell study reported that a combination agent (CP-AcT) composed of palmitoyl copper peptide (pal-GHK-Cu) and acetyl tyrosine promoted melanin production and associated gene/protein changes in A375 and B16 melanoma cell lines under conditions that did not compromise cell viability. (PMID: 39632290) [PMID 39632290]
Independent test grades
No independent third-party test data is available for Palmitoyl Tripeptide-1 yet. Our test grades are aggregated from Finnrick, which independently tests a subset of research peptides — many approved drugs and newer or niche compounds aren't covered.
Research literature (5)
Consolidated from PubMed — each links to the original record.
- Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism.
Wang C, Song T, Zhang Y, Li N, Xie L, Xie M · Journal of cosmetic dermatology · 2026 · PMID 41527525
- Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective.
Mortazavi SM, Mohammadi Vadoud SA, Moghimi HR · BioImpacts : BI · 2025 · PMID 39963574
- Palmitoyl copper peptide and acetyl tyrosine complex enhances melanin production in both A375 and B16 cell lines.
Hong M, Gui Y, Xu J, Zhao X, Jiang C, Zhao J · Biochemical and biophysical research communications · 2025 · PMID 39632290
- Development of a LC-MS/MS method to monitor palmitoyl peptides content in anti-wrinkle cosmetics.
Chirita RI, Chaimbault P, Archambault JC, Robert I, Elfakir C · Analytica chimica acta · 2009 · PMID 19393372
- Rapid complexing of oxoacylglycerols with amino acids, peptides and aminophospholipids.
Kurvinen JP, Kuksis A, Ravandi A, Sjövall O, Kallio H · Lipids · 1999 · PMID 10230725
FAQ
- What is Palmitoyl Tripeptide-1?
- Palmitoyl Tripeptide-1 (147732-56-7, L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-, Palmitoyl oligopeptide) is classified under copper & cosmetic signal peptides. Research goals associated with it include skin, hair & pigmentation.
- Is Palmitoyl Tripeptide-1 FDA-approved?
- The regulatory status of Palmitoyl Tripeptide-1 is not established in our sources.
- What does the research on Palmitoyl Tripeptide-1 say?
- peptideone aggregates 5 references from PubMed for Palmitoyl Tripeptide-1. The summary on this page digests them with citations; we summarize sources and make no efficacy claims.