Selank
Research onlyAlso known as: 129954-34-3, Selanc, Thr-Lys-Pro-Arg-Pro-Gly-Pro, TS9JR8EP1G, L-Proline, L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-, Threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline, DTXSID701029276, L-Proline, 1-(N-(1-(N2-(1-(N2-L-threonyl-L-lysyl)-L-prolyl)-L-arginyl)-L-prolyl)glycyl)-
Selank (129954-34-3, Selanc, Thr-Lys-Pro-Arg-Pro-Gly-Pro) is classified under nootropic & regulatory peptides, sold for research use only and not approved for human consumption.
Read the full guide: what the research shows on Selank →What the research says
Aggregated from the cited literature below. We summarize sources — we don't author claims.
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro; a tuftsin analogue) is described in the provided literature as a neuroactive heptapeptide with reported anti-anxiety and nootropic-related effects in preclinical rat studies, and as a peptide discussed in the context of peptide therapeutics for nervous-system recovery. (PMIDs: 41490200, 31625062, 30255741, 28280289, 14552529)
Mechanism (as reported)
Research described Selank as an allosteric modulator affecting [3H]GABA binding, including positive allosteric modulation and non-cumulative/additive patterns when combined with some benzodiazepines; the work also hypothesized/linked these effects to subtype-selective, concentration-dependent allosteric modulation of GABA receptors. (PMIDs: 30255741)
Key findings (each cites a source)
- A review of therapeutic peptides in orthopaedics described neuroactive peptides such as selank (along with semax and dihexa) as enhancing brain-derived neurotrophic factor (BDNF) and HGF/c-Met pathways important to neuroplasticity, while stating there is a current lack of clinical trials. [PMID 41490200]
- In a rat morphine withdrawal model, a study reported that Selank attenuated aversive signs of morphine withdrawal (using a naloxone-precipitated withdrawal paradigm) and increased tactile sensitivity compared with an active control group. [PMID 36322304]
- In rats with ethanol exposure/withdrawal paradigms, research reported that Selank prevented ethanol-induced memory and attention disturbances and was associated with prevention of ethanol-induced increases in BDNF content in the hippocampus and prefrontal cortex in ex vivo experiments. [PMID 31625062]
- A behavioral study reported that Selank enhanced diazepam-associated anxiolytic effects in unpredictable chronic mild stress conditions in rats, with specific elevated-plus-maze findings describing effects of individual versus combined administration patterns. [PMID 28280289]
- A molecular/ligand-receptor analysis reported that Selank affected [3H]GABA binding as a positive allosteric modulator and described interaction patterns with benzodiazepines that were characterized as non-cumulative and differing from either substance individually, supporting a proposed GABA receptor allosteric mechanism. [PMID 30255741]
- In a rat model of acute alcohol withdrawal (ethanol-preferring animals with prolonged ethanol exposure), a study reported that Selank eliminated anxiety induced by ethanol withdrawal and prevented formation of mechanical allodynia without affecting ethanol consumption in the described experimental setting. [PMID 24913576]
- A study of stress effects reported that chronic foot-shock stress induced specific morphological degenerative changes in rat liver, and that Selank administration reduced the intensity of stress-induced degenerative changes, with dose-dependent restoration of nucleus/cytoplasm ratio in hepatocytes in some groups. [PMID 31243679]
- In a conditioned active avoidance reflex study, research reported that Selank significantly activated learning in rats with initially poor learning ability, with improvements in correct solutions and reductions in errors over repeated administration, and described a comparison with piracetam in terms of time course/dynamics. [PMID 14552529]
Independent HPLC purity tests (255)
Real third-party HPLC results aggregated from Peptigrity, each attributed to the lab that ran it — average purity 99.6% across 255 tests. Not our verdict.
Labs: Janoshik Labs, Vanguard, Kovera Labs, Accurate Test Lab, Bioviridian, Ethos Analytics, ILS Laboratories, MDx BioAnalytical Laboratory.
| Vendor | HPLC purity | Lab | Date |
|---|---|---|---|
| penguinpeptides.com | 99.62% | Janoshik Labs | — |
| onedaycompounds.com | 99.39% | Vanguard | 2026-07-13 |
| ascend.science peptides | 99.80% | Kovera Labs | 2026-07-09 |
| ascend.science peptides | 99.71% | Kovera Labs | 2026-07-09 |
| biopeptitech.com | 99.76% | Accurate Test Lab |
Research literature (10)
Consolidated from PubMed — each links to the original record.
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Rahman OF, Lee SJ, Seeds WA · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026 · PMID 41490200
- Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.
Konstantinopolsky MA, Chernyakova IV, Kolik LG · Bulletin of experimental biology and medicine · 2022 · PMID 36322304
- The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.
Leonidovna YA, Aleksandrovna SM, Aleksandrovna TA, Aleksandrovna BO, Fedorovich MN, Aleksandrovna AL · Current reviews in clinical and experimental pharmacology · 2021 · PMID 32621722
- Functional Connectomic Approach to Studying Selank and Semax Effects.
Panikratova YR, Lebedeva IS, Sokolov OY, Rumshiskaya AD, Kupriyanov DA, Kost NV · Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2020 · PMID 32342318
- Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.
Fomenko EV, Bobyntsev II, Ivanov AV, Belykh AE, Andreeva LA, Myasoedov NF · Bulletin of experimental biology and medicine · 2019 · PMID 31243679
- Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.
Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, Durnev AD · Bulletin of experimental biology and medicine · 2019 · PMID 31625062
FAQ
- What is Selank?
- Selank (129954-34-3, Selanc, Thr-Lys-Pro-Arg-Pro-Gly-Pro) is classified under nootropic & regulatory peptides, sold for research use only and not approved for human consumption. Research goals associated with it include cognitive & mood.
- Is Selank FDA-approved?
- No. Selank is sold for research use only and is not approved for human consumption.
- What does the research on Selank say?
- peptideone aggregates 10 references from PubMed for Selank. The summary on this page digests them with citations; we summarize sources and make no efficacy claims.