MOTS-c vs Humanin
A factual side-by-side from public databases — chemical identity, literature volume, and attributed independent-test coverage. Not a recommendation; we don't rank one above the other.
MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a mitochondrial-derived peptide that consists of 16 amino acids and is encoded by the mitochondrial 12S rRNA region. Research has reported that MOTS-c can be transferred to the nucleus during metabolic stress and regulate nuclear gene expression, and that it is associated with regulation of metabolic homeostasis and insulin sensitivity, with reported links to age- and metabolism-related diseases. It has also been studied in cancer biology, where reports describe reduced levels in ovarian cancer tissues/serum and an inhibitory effect on ovarian cancer cell progression via interactions involving LARS1 ubiquitination and USP7-mediated deubiquitination.
Humanin is described as a mitochondrial-derived peptide encoded by mitochondrial DNA (mtDNA). Research has investigated humanin as a cytoprotective polypeptide involved in cellular stress responses and apoptosis-related regulation, and it has been discussed in contexts including metabolic regulation, cardiovascular disorders, cancer/degenerative diseases, and reproductive/testicular functions. (PMIDs: 33130077, 32680738, 30582721, 34534645)
| MOTS-c | Humanin | |
|---|---|---|
| Family | Mitochondrial-derived & protective | Mitochondrial-derived & protective |
| Research goals | Metabolic & weight, Longevity & cellular aging | Longevity & cellular aging |
| Amino acids | — | — |
| Molecular formula | C101H152N28O22S2 | C119H204N34O32S2 |
| Molecular weight | 2174.6 g/mol | 2687.2 g/mol |
| CAS number | 1627580-64-6 | 330936-69-1 |
| Approx. half-life | — | — |
| Regulatory status | Research only | Research only |
| WADA status | — | — |
| Evidence maturity | — | — |
| Research references | 8 | 8 |