GHRP-2
Research onlyAlso known as: Pralmorelin, 158861-67-7, KP-102, D-Alanyl-3-(2-naphthalenyl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide, pralmorelina, pralmoreline, E6S6E1F19M, KP 102
GHRP-2 (Pralmorelin, 158861-67-7, KP-102) is classified under ghrelin / gh secretagogues, sold for research use only and not approved for human consumption.
Read the full guide: what the research shows on GHRP-2 →What the research says
Aggregated from the cited literature below. We summarize sources — we don't author claims.
GHRP-2 (also called pralmorelin and others) is described as a synthetic growth hormone-releasing peptide that mimics ghrelin and can increase plasma GH levels. Research has included diagnostic exploration for GH deficiency/hypothalamo-pituitary function and studies of appetite/food intake and downstream signaling pathways. (PMIDs: 15230633, 15699539, 9798733, 9688350)
Mechanism (as reported)
Cell and culture studies reported that GHRP-2 does not act via the human growth hormone-releasing factor (GRF) receptor in GC cells (PMID: 9798733). In cultured human acromegalic tumor cells, research concluded that GHRP-2 stimulated GH secretion mainly via a PKC pathway (with reported differences versus GHRH-related signaling) and did not act on the same receptor as GHRH on those tumor-derived somatotrophs. (PMID: 9688350)
Key findings (each cites a source)
- Pralmorelin is described as GHRP-2 and a series of synthetic growth hormone-releasing peptides were developed; the work describes pralmorelin/GHRP-2 as orally active and synthetic, with activity related to mimicking ghrelin. (PMIDs: 15230633) [PMID 15230633]
- Research reported that pralmorelin/GHRP-2 increased plasma GH levels in healthy subjects, while the effect was significantly lower in patients with GH deficiency; a receiver-operating characteristic analysis provided a GH peak cut-off threshold value of 15.0 microg/L for identifying GH deficiency. (PMIDs: 15230633) [PMID 15230633]
- A human study reported that acute GHRP-2 increased food intake in lean healthy men during an ad libitum buffet meal after subcutaneous infusion, and that serum GH levels rose during infusion. (PMIDs: 15699539) [PMID 15699539]
- In rat pituitary GC cells, research reported that GHRP-2 did not alter intracellular cAMP, [Ca2+]i, or GH secretion in cells lacking the human GRF receptor, and concluded that GHRP-2 does not act through the GRF receptor. (PMIDs: 9798733) [PMID 9798733]
- In cultured human acromegalic tumor cells, research reported that application of GHRP-2 increased GH secretion from all tested tumor cultures and that the study concluded GHRP-2 increases GH secretion mainly via the PKC pathway (with reported differences from the effects of GHRH). (PMIDs: 9688350) [PMID 9688350]
- In an arthritic rat model, research reported that GHRP-2 administration ameliorated external arthritis symptoms and decreased serum IL-6 levels; in vitro, peritoneal macrophage cultures exposed to GHRP-2 prevented endotoxin-induced IL-6 and decreased nitrite/nitrate release. (PMIDs: 9688350) [PMID 9688350]
- An analytical study in an anti-doping context reported identification of a novel heptapeptide described as a glycine analogue of GHRP-2 in a seized injection vial, using liquid chromatography coupled to high-resolution tandem mass spectrometry and de novo sequencing. (PMIDs: 30051972) [PMID 30051972]
Independent HPLC purity tests (41)
Real third-party HPLC results aggregated from Peptigrity, each attributed to the lab that ran it — average purity 99.2% across 41 tests. Not our verdict.
Labs: Janoshik Labs, MZ Biolabs, Bioviridian, freedomdiagnosticstesting.com, Vanguard Laboratory, BioRegen, SR Bio Labs, Analytical Formulations Inc.
| Vendor | HPLC purity | Lab | Date |
|---|---|---|---|
| corixlabs.co.uk | 99.50% | Janoshik Labs | 2026-06-25 |
| blueskypeptide.com | 99.49% | MZ Biolabs | 2026-06-18 |
| myoasislabs peptides | 99.90% | Bioviridian | 2026-06-15 |
| RCpeptides | 98.04% | Janoshik Labs | 2026-05-06 |
| myoasislabs peptides | 98.80% | Bioviridian |
Research literature (21)
Consolidated from PubMed — each links to the original record.
- Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.
Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J · Translational andrology and urology · 2020 · PMID 32257855
- Preoperative growth hormone (GH) peak values during a GH releasing peptide-2 test reflect the severity of hypopituitarism and the postoperative recovery of GH secretion in patients with non-functioning pituitary adenomas.
Soga A, Fukuda I, Kobayashi S, Tahara S, Morita A, Sugihara H · Endocrine journal · 2020 · PMID 31776295
- Identification of a novel growth hormone releasing peptide (a glycine analogue of GHRP-2) in a seized injection vial.
Popławska M, Błażewicz A · Drug testing and analysis · 2019 · PMID 30051972
- Analysis of new growth promoting black market products.
Krug O, Thomas A, Malerød-Fjeld H, Dehnes Y, Laussmann T, Feldmann I · Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2018 · PMID 29864719
- The Safety and Efficacy of Growth Hormone Secretagogues.
Sigalos JT, Pastuszak AW · Sexual medicine reviews · 2018 · PMID 28400207
- Evaluation of growth hormone-releasing peptide-2 for diagnosis of thyrotropin-producing pituitary adenomas.
Kageyama K, Sakihara S, Kameda W, Sugiyama A, Takayasu S, Terui K · Endocrine journal · 2018 · PMID 29973439
FAQ
- What is GHRP-2?
- GHRP-2 (Pralmorelin, 158861-67-7, KP-102) is classified under ghrelin / gh secretagogues, sold for research use only and not approved for human consumption. Research goals associated with it include gh axis support.
- Is GHRP-2 FDA-approved?
- No. GHRP-2 is sold for research use only and is not approved for human consumption.
- What does the research on GHRP-2 say?
- peptideone aggregates 21 references from PubMed for GHRP-2. The summary on this page digests them with citations; we summarize sources and make no efficacy claims.