GHRP-2
Research onlyAlso known as: Pralmorelin, 158861-67-7, KP-102, D-Alanyl-3-(2-naphthalenyl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide, pralmorelina, pralmoreline, E6S6E1F19M, L-Lysinamide, D-alanyl-3-(2-naphthalenyl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-
GHRP-2 (Pralmorelin, 158861-67-7, KP-102) is classified under ghrelin / gh secretagogues, sold for research use only and not approved for human consumption.
Read the full guide: what the research shows on GHRP-2 →What the research says
Aggregated from the cited literature below. We summarize sources — we don't author claims.
GHRP-2 (also called pralmorelin and others) is described as a synthetic growth hormone-releasing peptide that mimics ghrelin and can increase plasma GH levels. Research has included diagnostic exploration for GH deficiency/hypothalamo-pituitary function and studies of appetite/food intake and downstream signaling pathways. (PMIDs: 15230633, 15699539, 9798733, 9688350)
Mechanism (as reported)
Cell and culture studies reported that GHRP-2 does not act via the human growth hormone-releasing factor (GRF) receptor in GC cells (PMID: 9798733). In cultured human acromegalic tumor cells, research concluded that GHRP-2 stimulated GH secretion mainly via a PKC pathway (with reported differences versus GHRH-related signaling) and did not act on the same receptor as GHRH on those tumor-derived somatotrophs. (PMID: 9688350)
Key findings (each cites a source)
- Pralmorelin is described as GHRP-2 and a series of synthetic growth hormone-releasing peptides were developed; the work describes pralmorelin/GHRP-2 as orally active and synthetic, with activity related to mimicking ghrelin. (PMIDs: 15230633) [PMID 15230633]
- Research reported that pralmorelin/GHRP-2 increased plasma GH levels in healthy subjects, while the effect was significantly lower in patients with GH deficiency; a receiver-operating characteristic analysis provided a GH peak cut-off threshold value of 15.0 microg/L for identifying GH deficiency. (PMIDs: 15230633) [PMID 15230633]
- A human study reported that acute GHRP-2 increased food intake in lean healthy men during an ad libitum buffet meal after subcutaneous infusion, and that serum GH levels rose during infusion. (PMIDs: 15699539) [PMID 15699539]
- In rat pituitary GC cells, research reported that GHRP-2 did not alter intracellular cAMP, [Ca2+]i, or GH secretion in cells lacking the human GRF receptor, and concluded that GHRP-2 does not act through the GRF receptor. (PMIDs: 9798733) [PMID 9798733]
- In cultured human acromegalic tumor cells, research reported that application of GHRP-2 increased GH secretion from all tested tumor cultures and that the study concluded GHRP-2 increases GH secretion mainly via the PKC pathway (with reported differences from the effects of GHRH). (PMIDs: 9688350) [PMID 9688350]
- In an arthritic rat model, research reported that GHRP-2 administration ameliorated external arthritis symptoms and decreased serum IL-6 levels; in vitro, peritoneal macrophage cultures exposed to GHRP-2 prevented endotoxin-induced IL-6 and decreased nitrite/nitrate release. (PMIDs: 9688350) [PMID 9688350]
- An analytical study in an anti-doping context reported identification of a novel heptapeptide described as a glycine analogue of GHRP-2 in a seized injection vial, using liquid chromatography coupled to high-resolution tandem mass spectrometry and de novo sequencing. (PMIDs: 30051972) [PMID 30051972]
Independent HPLC purity tests (34)
Real third-party HPLC results aggregated from Peptigrity, each attributed to the lab that ran it — average purity 99.2% across 34 tests. Not our verdict.
Labs: MZ Biolabs, Janoshik Labs, freedomdiagnosticstesting.com, Vanguard Laboratory, BioRegen, SR Bio Labs, Analytical Formulations Inc, liquilabs.
| Vendor | HPLC purity | Lab | Date |
|---|---|---|---|
| blueskypeptide.com | 99.49% | MZ Biolabs | 2026-06-18 |
| RCpeptides | 98.04% | Janoshik Labs | 2026-05-06 |
| bluumpeptides.com | 99.22% | freedomdiagnosticstesting.com | 2026-04-16 |
| corepeptides.com | 99.10% | Vanguard Laboratory | 2026-04-02 |
| corepeptides.com | 99.09% | Vanguard Laboratory |
Research literature (11)
Consolidated from PubMed — each links to the original record.
- Identification of a novel growth hormone releasing peptide (a glycine analogue of GHRP-2) in a seized injection vial.
Popławska M, Błażewicz A · Drug testing and analysis · 2019 · PMID 30051972
- The Safety and Efficacy of Growth Hormone Secretagogues.
Sigalos JT, Pastuszak AW · Sexual medicine reviews · 2018 · PMID 28400207
- Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats.
Granado M, Priego T, Martín AI, Villanúa MA, López-Calderón A · American journal of physiology. Endocrinology and metabolism · 2005 · PMID 15507538
- Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men.
Laferrère B, Abraham C, Russell CD, Bowers CY · The Journal of clinical endocrinology and metabolism · 2005 · PMID 15699539
- Pralmorelin: GHRP 2, GPA 748, growth hormone-releasing peptide 2, KP-102 D, KP-102 LN, KP-102D, KP-102LN.
Drugs in R&D · 2004 · PMID 15230633
- Pharmacological characteristics of KP-102 (GHRP-2), a potent growth hormone-releasing peptide.
Doi N, Hirotani C, Ukai K, Shimada O, Okuno T, Kurasaki S · Arzneimittel-Forschung · 2004 · PMID 15646370
- Effects of the administration of growth hormone-releasing peptide-2 (GHRP-2) orally by gavage and in feed on growth hormone release in swine.
FAQ
- What is GHRP-2?
- GHRP-2 (Pralmorelin, 158861-67-7, KP-102) is classified under ghrelin / gh secretagogues, sold for research use only and not approved for human consumption. Research goals associated with it include gh axis support.
- Is GHRP-2 FDA-approved?
- No. GHRP-2 is sold for research use only and is not approved for human consumption.
- What does the research on GHRP-2 say?
- peptideone aggregates 11 references from PubMed for GHRP-2. The summary on this page digests them with citations; we summarize sources and make no efficacy claims.