Sermorelin
Status unknownAlso known as: Sermorelina, 86168-78-7, Sermoreline, Sermorelinum, DTXSID70903978, 89243S03TE, TYR-ALA-ASP-ALA-ILE-PHE-THR-ASN-SER-TYR-ARG-LYS-VAL-LEU-GLY-GLN-LEU-SER-ALA-ARG-LYS-LEU-LEU-GLN-ASP-ILE-MET-SER-ARG-NH2, CHEBI:9118
Sermorelin (Sermorelina, 86168-78-7, Sermoreline) is classified under ghrh analogs.
What the research says
Aggregated from the cited literature below. We summarize sources — we don't author claims.
Sermorelin is discussed in the provided sources as a growth hormone secretagogue/growth hormone releasing hormone (GHRH) synthetic analog that is considered among compounds affecting GH/IGF-1 signaling pathways, and it also appears in research focused on doping detection and analytical stability/detection methods. (PMIDs: 41490200, 41966639, 34665524, 32257855, 37806509, 36787346)
Mechanism (as reported)
Research described sermorelin as part of the growth hormone secretagogues, reported to be GH and IGF-1 stimulators, and discussed in the context of activating IGF-1 signaling and pathways related to tissue repair/satellite cell involvement. (PMIDs: 41490200, 41966639, 32257855, 34665524)
Key findings (each cites a source)
- A review on therapeutic peptides in orthopaedics lists sermorelin among growth hormone secretagogues that are reported to activate IGF-1 signaling and satellite cell repair, and it notes that there is a lack of clinical trials despite promising preclinical studies. [PMID 41490200]
- A narrative review on peptide therapies for musculoskeletal injuries in sports medicine includes sermorelin among prominent approved/unapproved peptides marketed direct to patients and states that rigorous human safety data are scarce for many unapproved peptides. [PMID 41966639]
- Research investigated in vitro metabolism and detection of GHRH synthetic analogs including sermorelin in fortified urine, identifying multiple metabolites and using them to develop a sensitive LC-MS/MS method for detection to support evidence of GHRH administration. [PMID 34665524]
- A review addressing growth hormone secretagogues in body composition discussed sermorelin as a GH and IGF-1 stimulator and described that data on clinical effects remain limited, creating opportunities for future investigation. [PMID 32257855]
- Analytical work on in-house standards derived from doping peptides evaluated enzymatic and serum stability of sermorelin fragments (e.g., Sermorelin (1-11), (13-20), (22-29)) and reported that selected sermorelin fragment(s) (including Sermorelin (22-29)) can be considered stable to enzyme and blood treatment and used as internal standards in quantification workflows. [PMID 37688464]
- A validated urine method for detecting GHRH analogs reported inclusion of sermorelin forms (including sermorelin (GRF 1-29) and sermorelin (3-29)-NH2) using a triple quadrupole UHPLC/MS-MS approach with SPE, describing sensitivity and performance characteristics aligned with anti-doping laboratory screening requirements. [PMID 37806509]
- A capillary electrophoresis study proposed analysis of GHRH analogs including sermorelin (and CJC-1293) and reported chiral separation of enantiomeric/basic analogs and application to urine after desalting, with method-sensitivity results reported as limits of detection. [PMID 36787346]
Independent test grades (7 vendors)
Aggregated from Finnrick (independent testing). Their grades, attributed — not our verdict.
| Vendor | Grade | Score |
|---|---|---|
| NuLife Peptides | A | 7.9 |
| Qing Li Peptide | C | 7.6 |
| ZLZ Peptide | B | 6.8 |
| HK Peptides | D | 6.6 |
| Shanghai Sigma Audley SSA | F | 6.5 |
| Peptide-S | C | 5.4 |
| SRY Labs | D | 5.1 |
Research literature (8)
Consolidated from PubMed — each links to the original record.
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Rahman OF, Lee SJ, Seeds WA · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026 · PMID 41490200
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
Mendias CL, Awan TM · Sports medicine (Auckland, N.Z.) · 2026 · PMID 41966639
- Online large volume sample staking preconcentration and separation of enantiomeric GHRH analogs by capillary electrophoresis.
Otin J, Tran NT, Benoit A, Buisson C, Taverna M · Electrophoresis · 2023 · PMID 36787346
- In-house standards derived from doping peptides: Enzymatic and serum stability and degradation profile of GHRP and GHRH-related peptides.
González-López NM, Guerra-Acero-Turizo LM, Blanco-Medina I, Barragán-Cárdenas AC, Ramírez-Celis DA, Martínez-Ramírez JA · Biomedical chromatography : BMC · 2023 · PMID 37688464
- Cationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samples.
Cristea CD, Radu M, Toboc A, Stan C, David V · Analytical biochemistry · 2023 · PMID 37806509
- Advances in the detection of growth hormone releasing hormone synthetic analogs.
Memdouh S, Gavrilović I, Ng K, Cowan D, Abbate V · Drug testing and analysis · 2021 · PMID 34665524
- Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.
Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J · Translational andrology and urology · 2020 · PMID 32257855
- Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?
Walker RF · Clinical interventions in aging · 2006 · PMID 18046908
FAQ
- What is Sermorelin?
- Sermorelin (Sermorelina, 86168-78-7, Sermoreline) is classified under ghrh analogs. Research goals associated with it include gh axis support.
- Is Sermorelin FDA-approved?
- The regulatory status of Sermorelin is not established in our sources.
- What does the research on Sermorelin say?
- peptideone aggregates 8 references from PubMed for Sermorelin. The summary on this page digests them with citations; we summarize sources and make no efficacy claims.